The Lodhi Dynasty was the first and last Afghan dynasty to rule in South Asia, with the exception of Sher Shah Suri, the only other Afghan who ruled this region. The Lodhi elders served in the court of Firuz Shah and Khizar Khan and held positions of responsibility. Buhlul Lodhi, the founder of the dynasty, was the governor of Sarhind. When the Saiyids became weak, he first occupied the province of Punjab and later on captured the throne of Delhi. His coronation was held on April 19, 1451. He took the title of Sultan Abul Muzzaffar Buhlul Shah Ghazi. In the following era of anarchy, there were a number of attempts to destabilize the newly established rule. But with the help of the Afghans, Buhlul managed to secure the foundations of the House of Lodhis. He also managed to capture a number of nearby states that had become independent in the final days of the Tughluqs and Saiyids.

When Buhlul died in July 1489, his son Nizam Khan succeeded him. Nizam took over the crown on July 17, 1489. He assumed the title of Sikandar Shah. Sikandar proved to be the most capable ruler of the Lodhi Dynasty. He not only managed to crush the revolts of his relatives, but was also able to establish just administration in India. He was the founder of the historical city of Agra. Like his father, Sikandar also died a natural death in November 1516.